Clesacostat tromethamine

PF-05221304 (Clesacostat) is a potent, selective ACC inhibitor with IC50 values of 13 nM and 9 nM for hACC1 and hACC2, respectively. It effectively suppresses hepatic de novo lipogenesis in vivo and has demonstrated a favorable safety profile regarding thrombocytopenia risk in non-human primate models, supporting its use in metabolic disease research.