AR antagonist 10
Compound Y5 is a potent, orally bioavailable androgen receptor (AR) antagonist (IC50 = 0.04 μM) with a dual mechanism disrupting AR dimerization and promoting its proteasomal degradation. It is effective against resistant AR mutants and has demonstrated in vivo efficacy in inhibiting LNCaP xenograft tumor growth, supporting its use in prostate cancer research.
Product Specifications
CAS Number
3068489-78-8
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
O=C (NC1=NC (=NS1) CN2CCOCC2) C=3C=COC=4C=CC (Cl) =CC4C3
Molecular Formula
C18H17ClN4O3S
Molecular Weight
404.871
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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