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EGFR/VEGFR2-IN-3

EGFR/VEGFR2-IN-3 (compound 9) is a dual inhibitor of EGFR and VEGFR-2 with IC50 values of 0.129 μM and 0.142 μM, respectively, and shows weaker activity against COX-2. This small molecule induces apoptosis and G2/M phase cell cycle arrest in vitro, supporting its investigation in oncology research for anti-angiogenic and anti-proliferative effects.

Product Specifications

CAS Number

710972-61-5

Field of Research

Cardiovascular Research, Cardiovascular Research; Cell Biology, Cell Biology, Signal Transduction

Smiles

O=C (NNC (=S) NC1=CC=C (C=C1) C) CSC2=NC=3C=CC=CC3C (=O) N2C4=CC=C (Cl) C=C4

Molecular Formula

C24H20ClN5O2S2

Molecular Weight

510.03

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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