PROTAC SMARCA2 degrader-23
PROTAC SMARCA2 degrader-23 (Example 1) is a potent and selective degrader of the SMARCA2 protein, demonstrating a DC50 below 100 nM. This compound is a valuable chemical probe for oncology research, enabling the study of SMARCA2 function in both cellular and in vivo cancer models.
Product Specifications
CAS Number
2892523-67-8
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
OC1=C (C=2C=C3C4 (CNC3=NN2) CCN (CC4) C5CN (CCOC=6C=C ([C@H] (C (=O) N7[C@H] (C (N[C@@H] (C) C8=CC=C (C=C8) C=9SC=NC9C) =O) C[C@@H] (O) C7) C (C) C) ON6) CC5) C=CC=C1
Molecular Formula
C47H57N9O6S
Molecular Weight
876.08
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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