MRT-68921 hydrochloride
MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively; inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK; reduces phospho-ATG13 and blocks autophagy in cells.
Product Specifications
CAS Number
2080306-21-2
Product Name Alternative
MRT 68921 hydrochloride | MRT68921 hydrochloride
Purity
>98% (HPLC)
Solubility
H2O: 10 mg/mL
Smiles
CN1CCC2=C (C1) C=CC (=C2) NC3=NC=C (C (=N3) NCCCNC (=O) C4CCC4) C5CC5.Cl.Cl
Molecular Formula
C25H35ClN6O
Molecular Weight
471.038
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[ (1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl) amino]-4-pyrimidinyl]amino]propyl]-, hydrochloride (1:2)
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