JMF4073

JMF4073 is a potent dual inhibitor of TMP and CMP kinases, with IC50 values of 0.16 μM and 0.17 μM, respectively. It demonstrates efficacy against wild-type Bcr-Abl-transformed myeloid cells in both in vitro and in vivo models, supporting its use in oncology research, particularly for studying leukemia cell proliferation and nucleotide metabolism.