LY 295427
LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor) . LY 295427 can be used for hypercholesterolemia research[1][2][3].
Product Specifications
CAS Number
152755-31-2
Product Name Alternative
Agisterol
UNSPSC
12352211
Target
LDLR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ly-295427.html
Purity
98.0
Solubility
Methanol : 15.91 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(CCC[C@H]([C@H]1CC[C@]2([C@@]3(CC[C@]4([C@@H]([C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)CC=C)[H])[H])[H])C)C
Molecular Formula
C30H52O
Molecular Weight
428.73
References & Citations
[1]Bowling N, et al. LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins. J Lipid Res. 1996 Dec;37 (12) :2586-98.|[2]George Chang, et al. Low density lipoprotein receptor up-regulation. Expert Opinion on Therapeutic Patents. Volume 9, 1999-Issue 5.|[3]Bensch WR, et al. Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters. J Pharmacol Exp Ther. 1999 Apr;289 (1) :85-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-M525632-1MG 1 mg
Mono-2-ethyl-5-carboxypentyl Terephthalate-d4 (MECPTP)
Sign In for Pricing
View Details ![ELL Mouse Monoclonal Antibody [Clone ID: OTI1H7]](https://cdn.genprice.uk/products/937/68dd18bb061270361e90898a/imageurl/cf810829.webp)
