Sirtinol
SIRT inhibitor
Product Specifications
Background
Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 µM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.
Product Name Alternative
2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
UNSPSC
41116105
Source
Synthetic
Purity
>98%
Weight
0.025
Format
Off-white to yellow crystals
Solubility
Soluble to 100 mM in DMSO
Molecular Formula
C26H22N2O2
Molecular Weight
394.47
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Grozinger CM., et al (2001) J.Biol.Chem. 276: 38837.
2. Mai A., et al (2005) J.Med.Chem. 48: 7789.
3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364.
4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823.
CAS Number
410536-97-9
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