What is the catalog number for Sirtinol?

The catalog number for Sirtinol is SIH-360-25MG.

What sizes are available for Sirtinol?

Sirtinol is available in the following size(s): 25 mg.

Is Sirtinol in stock?

Sirtinol is currently made to order / not held in immediate stock. Contact us for lead time.

Sirtinol

SIRT inhibitor

Product Specifications

Background

Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 µM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

CAS Number

410536-97-9

Product Name Alternative

2-[[ (2-Hydroxy-1-naphthalenyl) methylene]amino]-N- (1-phenylethyl) benzamide

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Epigenetics and Nuclear Signaling

Purity

>98%

Weight

0.025

Format

Off-white to yellow crystals

Solubility

Soluble to 100 mM in DMSO

Molecular Formula

C26H22N2O2

Molecular Weight

394.47

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Grozinger CM., et al (2001) J.Biol.Chem. 276: 38837. 2. Mai A., et al (2005) J.Med.Chem. 48: 7789. 3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364. 4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823.