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Dot1L-IN-8

Dot1L-IN-8 (Compound 15) is a potent and selective Dot1L inhibitor, demonstrating anti-proliferative activity against various leukemia cell lines including HL-60, K562, and MV4-11 with IC50 values ranging from 0.45 to 1.66 μM. This small molecule is a valuable chemical probe for epigenetic research, particularly in studying the role of H3K79 methylation in hematological malignancies in vitro.

Product Specifications

Field of Research

Epigenetics & Chromatin

Molecular Formula

C41H53N7O3S

Molecular Weight

723.97

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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