PAWI-2
PAWI-2 is a multi-targeting small molecule that activates p53 and inhibits Wnt/β-catenin and TBK1 phosphorylation, inducing apoptosis and cell cycle arrest. It reverses stemness and drug resistance in KRAS-dependent pancreatic cancer stem cells, demonstrating efficacy in both in vitro assays and in vivo orthotopic xenograft models.
Product Specifications
CAS Number
1448427-02-8
Field of Research
Cell Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C1N (C2=CC=C (C=C2) S (=O) (=O) N3C=4C=CC=CC4N (C) CC3) CCC1
Molecular Formula
C19H21N3O3S
Molecular Weight
371.45
Storage Conditions
-20°C
Notes
For research use only.
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