Tri-GalNAc-DBCO
Tri-GalNAc-DBCO is a coupling compound that facilitates targeted protein degradation. It binds the asialoglycoprotein receptor (ASGPR) to drive internalization and utilizes copper-free click chemistry to conjugate with azide-labeled antibodies. This enables research into targeted degradation both in vitro and in vivo for therapeutic discovery.
Product Specifications
CAS Number
2999748-27-3
Product Name Alternative
PROTAC
Field of Research
Pharmacology & Drug Discovery
Purity
99.92% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (1.91 mM) ; DMSO:80 mg/mL (46.22 mM)
Smiles
CC (=O) N[C@H]1C (OCCCCC (=O) NCCCCNC (=O) CCOCC (COCCC (=O) NCCCNC (=O) CCCCOC2O[C@H] (CO) [C@H] (O) [C@H] (O) [C@H]2NC (C) =O) (COCCC (=O) NCCCNC (=O) CCCCO[C@@H]2O[C@H] (O) [C@H] (O) [C@H] (O) [C@H]2NC (C) =O) NC (=O) CCCCC (=O) N2Cc3ccccc3C#Cc3ccccc32) O[C@H] (CO) [C@H] (O) [C@@H]1O
Molecular Formula
C82H127N11O29
Molecular Weight
1730.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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