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Anti-JAB1 Antibody Picoband® (monoclonal, 4G9)

Boster Bio Anti-JAB1 Antibody Picoband® (monoclonal, 4G9) catalog # M01849-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or JAB1, is a gene conserved from humans to Saccharomyces cerevisiae. It is a member of the MOV34 family. COPS5 is mapped to 8q13.1. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, and it is the only protein demonstrated to interact with MIF. COPS5, VHL, and TRC8 proteins appear to be linked both physically and functionally, and all 3 may participate in the development of kidney cancer. In addition to that, COPS5 is an essential cofactor for the apoptotic function of E2F1.

Synonyms

Peroxiredoxin-6;1.11.1.15;1-Cys peroxiredoxin;1-Cys PRX;24 kDa protein; Acidic calcium-independent phospholipase A2; aiPLA2;3.1.1.-; Antioxidant protein 2; Liver 2D page spot 40; Non-selenium glutathione peroxidase; NSGPx;1.11.1.9; Red blood cells page spot 12; PRDX6; AOP2, KIAA0106

Gene Name

COPS5

Gene ID

10987

UniProt

Q92905

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human JAB1 recombinant protein (Position: M8-S334) . Human JAB1 shares 99.4% amino acid (aa) sequence identity with mouse JAB1.

Clonality

Monoclonal

Clone

Clone: 4G9

Tissue Specificity

Widely expressed in fetal and adult tissues.

Applications

WB, IHC, ICC, IF, Flow Cytometry

Field of Research

Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Organelle Proteins, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Involved in redox regulation of the cell. Can reduce H (2) O (2) and short chain organic, fatty acid and phospholipid hydroperoxides.May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

References & Citations

1. Bianchi, E., Denti, S., Granata, A., Bossi, G., Geginat, J., Villa, A., Rogge, L., Pardi, R.Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature 404: 617-621, 2000. 2. Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) . 3. Hallstrom, T. C., Nevins, J. R. Jab1 is a specificity factor for E2F1-induced apoptosis.Genes Dev. 20: 613-623, 2006.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

25035 MW

Observed Molecular Weight

37 kDa

Applications Notes

6

Gene Name Synonym

Peroxiredoxin 6

Subcellular Location

Cytoplasm . Lysosome . Cytoplasmic vesicle . Also found in lung secretory organelles.

Protein Name

Peroxiredoxin-6

Isotype

Mouse IgG2b

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

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