NST-628
NST-628 is a pan-RAF molecular glue that stabilizes the RAF-MEK complex to block MEK phosphorylation and activation. This inhibitor is a valuable research tool for studying MAPK/ERK pathway dysregulation in cancer, applicable in both cellular and animal model studies.
Product Specifications
CAS Number
3002056-30-3
Product Name Alternative
NST 628, NST628, MEK, Raf
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
98.62% (May vary between batches)
Solubility
DMSO:80 mg/mL (163.78 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.76 mM)
Smiles
O=C1OC=2C=C (OC3=NC=CC=C3F) C=CC2C (=C1CC=4C=CN=C (NS (=O) (=O) NC) C4F) C
Molecular Formula
C22H18F2N4O5S
Molecular Weight
488.46
Storage Conditions
-20°C
Notes
For research use only.
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