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SIK-IN-1

SIK-IN-1 (Compound 53) is a highly potent, pan-SIK inhibitor with single-digit nM IC50 values against SIK1, SIK2, and SIK3. It modulates macrophage cytokine profiles by potently suppressing TNFα release and enhancing LPS-induced IL-10 production, making it a valuable tool for studying immunometabolism and inflammation in cellular models.

Product Specifications

CAS Number

3033846-29-3

Field of Research

Epigenetics & Chromatin, Signal Transduction

Smiles

C (#N) C=1N2C (=CN=C2C=CC1NC) C3=CC (OCC4 (N) CCCC4) =C (C#N) C (SC) =C3

Molecular Formula

C23H24N6OS

Molecular Weight

432.54

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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