T-Boc-Aminooxy-PEG12-NHS ester

This polyethylene glycol (PEG) -based linker, featuring a t-Boc-protected aminooxy group and an NHS ester, is specifically designed for constructing PROTAC molecules. It enables the conjugation of warhead ligands to E3 ubiquitin ligase binders, facilitating the development of degraders for both in vitro and in vivo target validation studies.