APC Anti-Human CD172a/b Antibody[SE5A5]
Product Specifications
Background
CD172a, also known as signal-regulatory protein α (SIRPα), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs) . The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPα was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells2.
Abbreviation
CD172a/b
Gene ID
140885
UniProt
O00241
Host
Mouse
Reactivity
Human
Target
SIRPa; SIRPb; SIRPalpha/beta; BIT; SHPS1; MFR; P84; PTPNS1; CD172 antigen-like family member A; CD172 antigen-like family member B
Clonality
Monoclonal
Clone
SE5A5
Conjugation
APC
Applications
FCM
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Product Datasheet
https://789.bio/ea/rxhhi9
Product MSDS
https://789.bio/eb/dqP0dD
Recommended Usage
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype
Mouse IgG1, κ
Available Sizes
Curated Selection
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