PROTAC AR-V7 degrader-1
Compound 6 is an orally active PROTAC that selectively degrades the androgen receptor splice variant AR-V7 via VHL recruitment, with a DC50 of 0.32 μM. It is a valuable research tool for studying castration-resistant prostate cancer models, demonstrating cellular efficacy in AR-V7-expressing 22Rv1 cells (EC50 = 0.88 μM) .
Product Specifications
CAS Number
2767440-24-2
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
C ([C@@H] (NC (CCCCOC1=CC=C (C=C1) C=2N=C (SC2) N3CCOCC3) =O) [C@@] (C) (C) C) (=O) N4[C@H] (C (N[C@@H] (C) C5=CC=C (C=C5) C=6SC=NC6C) =O) C[C@@H] (O) C4
Molecular Formula
C41H52N6O6S2
Molecular Weight
789.02
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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