MAC glucuronide phenol-linked SN-38
This compound, a pH-sensitive prodrug linker conjugate of SN-38, acts as a DNA topoisomerase I inhibitor. It demonstrates cytotoxic activity in vitro, with IC50 values of 113 ng/mL in L540cy cells and 67 ng/mL in Ramos cells. Its design is relevant for developing antibody-drug conjugates (ADCs) in oncology research.
Product Specifications
CAS Number
2246380-69-6
Field of Research
Pharmacology & Drug Discovery
Smiles
CCc1c2Cn3c (cc4c (COC (=O) [C@]4 (O) CC) c3=O) -c2nc2ccc (OCN (CCS (C) (=O) =O) C (=O) OCc3ccc (O[C@@H]4O[C@@H] ([C@@H] (O) [C@H] (O) [C@H]4O) C (O) =O) c (NC (=O) CN (C) C (=O) CCN4C (=O) C=CC4=O) c3) cc12
Molecular Formula
C50H54N6O20S
Molecular Weight
1091.06
Storage Conditions
-20°C
Notes
For research use only.
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