(3S,4S) -PF-06459988
Product Specifications
CAS Number
1858291-14-1
Target
Others, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Others, Angiogenesis
Bioactivity
(3S, 4S) -PF-06459988 is the less active S enantiomer of PF-06459988, a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR), exhibiting excellent selectivity against EGFR wild-type due to its minimally reactive electrophile, reducing off-target labeling likelihood.
Smiles
CO[C@@H]1CN(C[C@H]1COc1nc(Nc2cnn(C)c2)nc2[nH]cc(Cl)c12)C(=O)C=C
Molecular Formula
C19H22ClN7O3
Molecular Weight
431.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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