CZEN-002
CZEN-002 is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. (In Vitro) :α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus. (In Vivo) :α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions.
Product Specifications
CAS Number
581-05-5
Product Name Alternative
α-Melanocyte-Stimulating Hormone (MSH) amide
Purity
>98% (HPLC)
Solubility
H2O:50 mg/mL (30.03 mM; Need ultrasonic)
Smiles
OC[C@H] (NC (=O) [C@H] (Cc1ccc (O) cc1) NC (=O) [C@H] (CO) NC (C) =O) C (=O) N[C@@H] (CCSC) C (=O) N[C@@H] (CCC (=O) O) C (=O) N[C@@H] (Cc2cncn2) C (=O) N[C@@H] (Cc3ccccc3) C (=O) N[C@@H] (CCCNC (=N) N) C (=O) N[C@@H] (Cc5cnc4ccccc45) C (=O) NCC (=O) N[C@@H] (CCCCN) C (=O) N6CCC[C@H]6C (=O) N[C@H] (C (N) =O) C (C) C
Molecular Formula
C77H109N21O19S
Molecular Weight
1664.88
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(4S7S10S13S16S22S) -7- ((1H-imidazol-4-yl) methyl) -16- ((1H-indol-3-yl) methyl) -26-amino-22- ((S) -2- (((S) -1-amino-3-methyl-1-oxobutan-2-yl) carbamoyl) pyrrolidine-1-carbonyl) -10-benzyl-13- (3-guanidinopropyl) -4- ((2S5S8S11S) -8- (4-hydroxybenzyl) -511-bis (hydroxymethyl) -2- (2- (methylthio) ethyl) -471013-tetraoxo-36912-tetraazatetradecanamido) -5811141720-hexaoxo-6912151821-hexaazahexacosanoic acid
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