A2AR-antagonist-1
A2AR-antagonist-1 is an orally bioavailable, potent A2A receptor antagonist (IC50 = 29 nM) with demonstrated metabolic stability. It exhibits anti-tumor activity by reversing T-cell suppression, downregulating LAG-3/TIM-3 and upregulating effector molecules like IFN-γ and Granzyme B, making it a valuable tool for immuno-oncology research.
Product Specifications
CAS Number
2922920-71-4
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
CC1=C (C=CC=C1C2=NC (=NC (=C2) C3=CC (=O) N (C=C3) CC4=CC (=CC=C4) C (C) (C) O) N) C#N
Molecular Formula
C27H25N5O2
Molecular Weight
451.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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