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EIF4A3-IN-18

EIF4A3-IN-18 is a potent silvestrol analog that inhibits protein synthesis by disrupting eIF4F complex formation, with EC50 values in the low nanomolar range against various cellular targets. It exhibits significant cytotoxicity, particularly against cancer cell lines such as MBA-MB-231 and RMPI-8226, making it a valuable chemical probe for studying translation initiation in cancer pathogenesis research.

Product Specifications

CAS Number

1402931-84-3

Field of Research

Cell Biology

Smiles

O[C@]12[C@] ([C@@H] ([C@@H] (C (N (C) C) =O) [C@H]1O) C3=CC=CC=C3) (OC=4C2=C (OC) C=C (C#N) C4) C5=CC=C (OC) C=C5

Molecular Formula

C29H28N2O6

Molecular Weight

500.54

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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