PROTAC Axl Degrader 2
PROTAC Axl Degrader 2 is a potent and selective PROTAC Axl degrader with an IC50 of 1.61 μM. PROTAC Axl Degrader 2 shows anti-proliferation activity, anti-migration activity in vitro. PROTAC Axl Degrader 2 induces mehuosis[1].
Product Specifications
UNSPSC
12352005
Target
PROTACs; TAM Receptor
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-axl-degrader-2.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC(NC2=CC=C(C=C2)CNC(CCCCCNC3=CC=CC4=C3CN(C4=O)C5CCC(NC5=O)=O)=O)=NN1C6=CC=C(N=N6)C7=CC=CC=C7
Molecular Formula
C38H39N11O4
Molecular Weight
713.79
References & Citations
[1]Shi W, et al. Structure-based discovery of receptor tyrosine kinase AXL degraders with excellent anti-tumor activity by selectively degrading AXL and inducing methuosis. Eur J Med Chem. 2022; 234:114253.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6495997-01 0.1 mL
PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1) (MaxLight 550)
Ask
View Details MBS6495997-02 5x 0.1 mL
PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1) (MaxLight 550)
Ask
View Details