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EIF2S1 (Phospho-S51) Rabbit monoclonal antibody

Product Specifications

Background

Phosphorylation of the eukaryotic initiation factor 2 (eIF2) α subunit is a well-documented mechanism to downregulate protein synthesis under a variety of stress conditions. eIF2 binds GTP and Met-tRNAi and transfers Met-tRNA to the 40S subunit to form the 43S preinitiation complex. eIF2 promotes a new round of translation initiation by exchanging GDP for GTP, a reaction catalyzed by eIF2B . Kinases that are activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), or heme deficiency (HRI) can phosphorylate the α subunit of eIF2. This phosphorylation stabilizes the eIF2-GDP-eIF2B complex and inhibits the turnover of eIF2B. Induction of PKR by IFN-γ and TNF-α induces potent phosphorylation of eIF2α at Ser51.

Structure Composition

Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Product Name Alternative

EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha

Swiss Prot

P05198

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser51 of human EIF2S1

Conjugation

Unconjugated

Related Pathways

Translational Contral Regulation of elF2

Applications

WB

Dilution

WB (1/500 - 1/1000)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Phosphorylation

Molecular Weight

~ 42 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of EIF2S1 (pS51) protein.

Applications Notes

Western blot analysis of EIF2S1 (pS51) expression in K562 (A), C6 (B), NIH3T3 (C), Hela (D) whole cell lysates.

Host or Source

Rabbit

CAS Number

9007-83-4

Available Sizes

Curated Selection

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