EGFR/C797S-IN-1
EGFR/C797S-IN-1 is a potent and selective small molecule inhibitor of the EGFR C797S mutation with an IC50 of 0.128 μM. It demonstrates dose-dependent suppression of p-EGFR, leading to anti-proliferative activity in vitro and anti-tumor efficacy in vivo, making it a valuable tool for studying resistance mechanisms in non-small cell lung cancer.
Product Specifications
CAS Number
2378188-21-5
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N (C=1C2=C (C=C (OCC3CCN (C) CC3) C (OC) =C2) N=CN1) C4=CC=C (OC5=CC=CC=C5) C=C4
Molecular Formula
C28H30N4O3
Molecular Weight
470.56
Storage Conditions
-20°C
Notes
For research use only.
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