CCR7 Ligand 1
CCR7 Ligand 1 (CCR7-Cmp2105) is a potent allosteric antagonist of human CCR7 with a 3 nM Kd. This thiadiazole-dioxide ligand inhibits CCL19-induced arrestin recruitment (IC50 = 7.3 μM) . It serves as a key research tool for investigating CCR7-mediated immune cell migration and lymph node biology in both cellular and animal models.
Product Specifications
CAS Number
681514-83-0
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Smiles
CN (C) C (=O) c1c (C) ccc (NC2=NS (=O) (=O) N=C2N[C@@H] (c2ccc (C) o2) C (C) (C) C) c1O
Molecular Formula
C22H29N5O5S
Molecular Weight
475.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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