PKM2 activator 7
PKM2 activator 7 (Compd B4) is a PKM2 activator with the AC50 of 0.144 μM. PKM2 activator 7 suppresses DSS -induced colitis by inhibiting T cell growth in mouse colitis model[1].
Product Specifications
UNSPSC
12352005
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pkm2-activator-7.html
Smiles
C=C([C@H]1[C@H](O2)[C@H]3[C@@](O3)(C)CC/C=C(COC(F)(F)F)\CC1)C2=O
Molecular Formula
C16H19F3O4
Molecular Weight
332.31
References & Citations
[1]Ma L, et al. Design, synthesis, and biological evaluation of novel sesquiterpene lactone derivatives as PKM2 activators with potent anti-ulcerative colitis activities. Eur J Med Chem. 2024;272:116426.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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