ML224
ML224 (NCGC00242364) is a small molecule antagonist of the thyroid-stimulating hormone receptor (TSHR) . It is a research tool for investigating Graves' disease pathologies, including hyperthyroidism and orbitopathy, with demonstrated activity in both in vitro assays and in vivo animal models.
Product Specifications
CAS Number
1338824-21-7
Product Name Alternative
ANTAG 3, ANTAG3, ANTAG-3, ML224, ML-224, ML 224, NCGC 00242364, NCGC00242364, NCGC-00242364, thyrotropin receptor (TSHR), TSH Receptor, TSHReceptor
Field of Research
Pharmacology & Drug Discovery
Purity
99.14% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.28 mM) ; DMSO:80 mg/mL (152.21 mM)
Smiles
COc1ccc (cc1COc1c (C) cc (NC (C) =O) cc1C) C1Nc2ccccc2C (=O) N1Cc1ccco1
Molecular Formula
C31H31N3O5
Molecular Weight
525.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
NR5A1 (Steroidogenic Factor 1, Nuclear Receptor Subfamily 5, Group A, Member 1)
