SB-505124 hydrochloride
SB-505124 hydrochloride is a potent, selective, and orally active inhibitor of TGF-β type I receptors (ALK4/5/7) . It has been shown to inhibit IL-6 production in synovial explants and reduce Th17 differentiation in mice, making it a valuable tool for studying pathways in inflammation, autoimmunity, and cancer research such as colorectal cancer.
Product Specifications
CAS Number
356559-13-2
Product Name Alternative
SB 505124 hydrochloride, SB505124 hydrochloride, SB-505124 Hydrochloride, ALK4, ALK5, ALK7
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.64% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.38 mM) ; Methanol:120 mg/mL (322.7 mM) ; DMSO:40 mg/mL (107.57 mM)
Smiles
Cl.N=1C (=CC=CC1C) C=2N=C (NC2C=3C=CC=4OCOC4C3) C (C) (C) C
Molecular Formula
C20H22ClN3O2
Molecular Weight
371.86
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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