ZIP4H
ZIP4 homolog (ZIP4H), also known as testis expressed sequence 11 (Tex11) is a 947 amino acid (aa) X chromosome-encoded protein that is selectively expressed in primordial male germ cells. It associates with Nbs1 of the Mre11 protein complex which results in localization to areas of synaptonemal contact between meiotic chromosomes. During meiosis, ZIP4H promotes sister chromatid synapsis and crossover in response to programmed double stranded DNA breaks. ZIP4H deficiency leads to increased spermatocyte apoptosis and male sterility. Alternate splicing in mouse generates an additional isoform with a substitution (aa 691‑707) and truncation (aa 708‑947) at the C-terminus. Within aa 768‑947, mouse ZIP4H shares 44% and 73% aa sequence identity with human and rat ZIP4H, respectively.
Product Specifications
Synonyms
Testis expressed 11, testis expressed sequence 11, testis-expressed sequence 11 protein, Tex11, TGC1, TSGA3, ZIP4H
NCBI Gene ID
83558
UniProt
Q14AT2
Accession Number
NP_113561.2
Accession Number mRNA
NM_031384.2
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant Mouse ZIP4H
Clone
(#5E34)
Applications
WB
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Rat
Isotype
IgG2
Frequently Asked Questions
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