Proguanil
Proguanil is an antimalarial prodrug whose active metabolite, cycloguanil, inhibits Plasmodium dihydrofolate reductase (DHFR), disrupting parasite nucleotide synthesis. It is widely used in malaria research for both in vitro antimalarial assays and in vivo prophylactic studies in animal models.
Product Specifications
CAS Number
500-92-5
Product Name Alternative
Proguanil, Chloroguanide, Chlorguanide
Field of Research
Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery
Purity
99.60% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.76 mM) ; DMSO:120 mg/mL (472.94 mM) ; Ethanol:40 mg/mL (157.65 mM)
Smiles
ClC1=CC=C (C=C1) NC (=N) NC (=N) NC (C) C
Molecular Formula
C11H16ClN5
Molecular Weight
253.73
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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