HUP-46
HUP-46 is a BBB-penatrable modulator of αSyn dimerization and autophagy. HUP-46 reduces the ratio of pPP2A/PP2A, increases the autophagy marker LC3BII levels, and decreases αSyn dimerization. HUP-46 can be used for research of neurodegenerative diseases[1].
Product Specifications
CAS Number
[3007689-83-7]
UNSPSC
12352005
Target
Atg8/LC3; Autophagy; α-synuclein
Related Pathways
Autophagy; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=C(N2[C@@H](CCC2)C#N)SC(CCCC3=CC=CC=C3)=N1
Molecular Formula
C18H21N3S
Molecular Weight
311.44
References & Citations
[1]Pätsi HT, et al. 5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions. J Med Chem. 2024 Apr 11;67 (7) :5421-5436.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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