IRAK4-IN-4
IRAK4-IN-4 (Compound 15) is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, with an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM. IRAK4-IN-4 can be used for research of autoimmune diseases[1].
Product Specifications
CAS Number
[1850276-58-2]
Product Name Alternative
Hydroxypropyl Cellulose, Viscosity(5%):75-150mPa.s, MW 100000,Hydroxypropyl Cellulose, Viscosity(1%):1275-3500mPa.s,Hydroxypropyl Cellulose, Viscosity(2%):95000-105000mPa.s,BafA1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cyclic GMP-AMP Synthase; IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/irak4-in-4-1.html
Concentration
10mM
Purity
99.55
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=CC=CC=C2)N=C3C=C(C)C=CN31)C(C4=CC=CC=C4)=O
Molecular Formula
C22H16N2O2
Molecular Weight
340.37
Precautions
H302, H315, H319, H335
References & Citations
[1]One class has the naphthalene second dione compounds and its derivative of protease modification activities. CN107163044A.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
Available Sizes
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