Necrostatin-5
Necrostatin-5 (Nec-5) is a potent and selective RIP1 kinase inhibitor that blocks necroptotic cell death. It exhibits an EC50 of 240 nM in preventing TNF-α-induced necrosis in FADD-deficient Jurkat cells. This small molecule is a valuable research tool for investigating necroptosis in cellular models and related disease pathways.
Product Specifications
CAS Number
337349-54-9
Product Name Alternative
Nec-5, necroptosis, Necrostatin-5, RIPkinase, RIP kinase, RIP1
Field of Research
Cell Biology, Signal Transduction
Purity
98.03% (May vary between batches)
Solubility
DMSO:4.5 mg/mL (11.73 mM)
Smiles
O=C1C=2C3=C (SC2N=C (SCC#N) N1C4=CC=C (OC) C=C4) CCCC3
Molecular Formula
C19H17N3O2S2
Molecular Weight
383.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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