LDV-FITC

LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267) . LDV-FITC binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively) . LDV-FITC can be used to detect α4β1 integrin affinity[1][2].

Product Specifications

CAS Number

[1207610-07-8]

UNSPSC

12352209

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ldv-fitc.html

Purity

98.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)=O)=O)CC(O)=O)=O)C(C)C)=O)=O)C)=O)C)=O)CCCCNC(NC4=CC5=C(C=C4)C6(OC5=O)C7=C(C=C(C=C7)O)OC8=C6C=CC(O)=C8)=S)O

Molecular Formula

C69H81N11O17S

Molecular Weight

1368.51

References & Citations

[1]Hyduk SJ, et al. Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants. Blood. 2007 Jan 1;109 (1) :176-84.|[2]Chigaev A, et al. Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn (2+) or antibody activation. J Biol Chem. 2001 Dec 28;276 (52) :48670-8.