AV123
AV123 is a non-cytotoxic, small-molecule inhibitor of RIPK1 (IC50 = 12.12 μM) that selectively blocks TNF-α-induced necroptosis (EC50 = 1.7 μM) without affecting apoptosis. Its application in research extends to studying necroptosis-related pathologies, including ischemia-reperfusion injury, neurodegenerative diseases, and inflammatory conditions, in both cellular and animal models.
Product Specifications
CAS Number
233605-81-7
Field of Research
Cell Biology, Signal Transduction
Smiles
N (=O) (=O) C=1C=C2C (N=C (NCCCC) N2) =CC1
Molecular Formula
C11H14N4O2
Molecular Weight
234.25
Storage Conditions
-20°C
Notes
For research use only.
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