MK-2461

MK-2461 is a potent, ATP-competitive small molecule inhibitor targeting multiple proteins, with notable activity against activated c-Met (IC50 = 2.5 nM) . It is widely used in cancer research, particularly in studies of tumor growth and metastasis, and has been applied in both in vitro cellular assays and in vivo xenograft models.

Product Specifications

CAS Number

917879-39-1

Product Name Alternative

HGFR, MK2461, MK-2461, MK 2461, Inhibitor, inhibit, cMet, c-Met, c-Met (M1250T), c-Met (N1100), c-Met (Y1230C), c-Met (Y1230H), c-Met (Y1235D), c-Met/HGFR, cMet/HGFR

Field of Research

Signal Transduction

Purity

95.41% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.66 mM) ; DMSO:92 mg/mL (185.65 mM)