PD-1/PD-L1-IN 6

PD-1/PD-L1-IN 6 (Compound A13) is a potent small molecule inhibitor of the PD-1/PD-L1 immune checkpoint, exhibiting an IC50 of 132.8 nM. It demonstrates significant immunoregulatory activity in vitro, restoring T-cell function and enhancing interferon-γ secretion in co-culture models without significant cytotoxicity, supporting its use in immuno-oncology research.