JTP-117968
JTP-117968 is a potent and selective non-steroidal glucocorticoid receptor modulator (SGRM) with an IC50 of 6.8 nM. It demonstrates a dissociated profile, preferentially inhibiting transrepression over transactivation. This compound is a valuable research tool for investigating GR-mediated pathways in both cellular and animal models of inflammation and metabolic disease.
Product Specifications
CAS Number
2250132-99-9
Field of Research
Metabolism Research
Smiles
C ([C@@]12[C@] (C3 (CC=4C1=CC=C (C (NC5=C (C) N=CC=C5) =O) C4) CC3) (C[C@] ([C@@] (F) (F) F) (O) CC2) [H]) C6=CC=CC=C6
Molecular Formula
C31H31F3N2O2
Molecular Weight
520.59
Storage Conditions
-20°C
Notes
For research use only.
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