SW155246
SW155246 is a potent and selective DNMT1 inhibitor (IC50 = 1.2 μM) that reactivates silenced tumor suppressor genes, such as RASSF1, in cellular models like A549 lung carcinoma cells. This compound is a valuable chemical probe for epigenetic research, enabling the study of DNA methylation's role in cancer biology and gene expression both in vitro and in vivo.
Product Specifications
CAS Number
420092-79-1
Product Name Alternative
DNAMethyltransferase, DNMT1, DNMT1 inhibitor, DNMTs, DNA Methyltransferase, DNA MTases, cancer, mDNMT3A, Inhibitor, hDNMT1, inhibit, SW155246, SW-155246, SW 155246
Field of Research
Epigenetics & Chromatin
Purity
97.79% (May vary between batches)
Solubility
DMSO:50 mg/mL (132 mM)
Smiles
Oc1ccc (NS (=O) (=O) c2ccc (Cl) c (c2) [N+] ([O-]) =O) c2ccccc12
Molecular Formula
C16H11ClN2O5S
Molecular Weight
378.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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