SM-276001
SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer[1][2].
Product Specifications
CAS Number
[473930-22-2]
UNSPSC
12352005
Target
IFNAR; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sm-276001.html
Concentration
10mM
Purity
99.41
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC1=C2C(N(C(N2)=O)CC3=CN=C(C=C3)C)=NC(NCCCC)=N1
Molecular Formula
C16H21N7O
Molecular Weight
327.38
References & Citations
[1]Isobe Y, et al. Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers. J Med Chem. 2006 Mar 23;49 (6) :2088-95.|[2]Koga-Yamakawa E, et al. Intratracheal and oral administration of SM-276001: a selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer. Int J Cancer. 2013 Feb 1;132 (3) :580-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7
Available Sizes
Curated Selection
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