SM-276001

SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer[1][2].

Product Specifications

CAS Number

[473930-22-2]

UNSPSC

12352005

Target

IFNAR; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sm-276001.html

Concentration

10mM

Purity

99.41

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=C2C(N(C(N2)=O)CC3=CN=C(C=C3)C)=NC(NCCCC)=N1

Molecular Formula

C16H21N7O

Molecular Weight

327.38

References & Citations

[1]Isobe Y, et al. Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers. J Med Chem. 2006 Mar 23;49 (6) :2088-95.|[2]Koga-Yamakawa E, et al. Intratracheal and oral administration of SM-276001: a selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer. Int J Cancer. 2013 Feb 1;132 (3) :580-90.