SHP2-D26
SHP2-D26 is a potent, proteolysis-targeting chimera (PROTAC) that selectively degrades SHP2 by recruiting the VHL E3 ligase, requiring neddylation and proteasome activity. It is a valuable research tool for investigating SHP2-dependent signaling in cancer and RASopathies, applicable in both cellular and in vivo models.
Product Specifications
CAS Number
2458219-65-1
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C ([C@@H] (NC (CCCCCCCCN1CCN (C (CCC (NC2=C (Cl) C (SC=3C (N) =NC (=CN3) N4CCC (C) (N) CC4) =CC=C2) =O) =O) CC1) =O) [C@] (C) (C) C) (=O) N5[C@H] (C (N[C@@H] (C) C6=CC=C (C=C6) C=7SC=NC7C) =O) C[C@@H] (O) C5
Molecular Formula
C56H79ClN12O6S2
Molecular Weight
1115.9
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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