Anti-CD40 [A54 scFv]

Product Specifications

CAS Number

9007-83-4

Gene Name

[CD40]

NCBI Gene ID

958

Reactivity

Human

Storage Conditions

Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Specificity

A54 binds specifically to the D1 domain of CD40 (and can only bind to the intact i.e. non-truncated version of CD40 and when an AD2 peptide tag has not been added) and can recognise CD40 on a B cell line (BJAB). This scFv binds to CD40 (immobilized by amine coupling) with a KD within the range of 40nM. CD40 is a glycoprotein of the TNFR superfamily and is expressed on all mature B cells, dendritic cells, activated monocytes, some endothelial cells and some epithelium including the thymus. CD40 binds to the membrane protein CD154 of the TNF superfamily and this interaction is required for the seconfary immune responses and germinal centre formation.

Other Gene Names

[CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5]

Short Name

[CD40]

Other Product Names

[tumor necrosis factor receptor superfamily member 5 isoform 1; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily member 5; CD40 molecule; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40]