BX-912
BX-912 is a potent and selective cell-permeable inhibitor of PDK1 (IC50 = 12 nM), exhibiting over 10-fold selectivity against kinases such as C-Kit and PKC. It is a valuable chemical probe for studying the PI3K/PDK1/Akt signaling pathway in cancer research, enabling mechanistic investigations in both cellular and in vivo models.
Product Specifications
CAS Number
702674-56-4
Product Name Alternative
Apoptosis, BX 912, BX912, BX-912, Chk1, CDK2/CyclinE, Inhibitor, inhibit, VEGFR2 (KDR), PDK1, PDK-1, PKA
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
95.25% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7 mM) ; DMSO:87 mg/mL (184.58 mM) ; Ethanol:87 mg/mL (184.58 mM)
Smiles
Brc1cnc (Nc2cccc (NC (=O) N3CCCC3) c2) nc1NCCc1cnc[nH]1
Molecular Formula
C20H23BrN8O
Molecular Weight
471.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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