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Talaroterphenyl A

Talaroterphenyl A (compound 1) is a p-terphenyl derivative present in the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41412, which exhibits phosphodiesterase 4 (PDE4) inhibitory activity (IC50=1.2 μM) . Talaroterphenyl A also exhibits anti-inflammatory and anti-fibrotic activities, significantly reducing the mRNA levels of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β[1].

Product Specifications

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/talaroterphenyl-a.html

Smiles

OC1=C(C2=CC=CC=C2)C(OC(C)=O)=C(OC)C(C3=CC=CC=C3)=C1OC

Molecular Formula

C22H20O5

Molecular Weight

364.39

References & Citations

[1]Cai J, et al. Discovery of Oxidized p-Terphenyls as Phosphodiesterase 4 Inhibitors from Marine-Derived Fungi[J]. Journal of Natural Products, 2024.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

PDE4

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