XE 991 dihydrochloride
XE 991 dihydrochloride is a potent and selective blocker of Kv7 (KCNQ) potassium channels, including Kv7.1, Kv7.2, and Kv7.2/7.3 heteromers, with IC50 values ranging from 0.6 to 0.98 μM. It is widely used in neuroscience research to inhibit the neuronal M-current, facilitating studies of neuronal excitability, synaptic plasticity, and related neurological disorders in both in vitro and in vivo models.
Product Specifications
CAS Number
122955-13-9
Product Name Alternative
KcsA, inhibit, Kv7.1, Kv7.1 channel, Kv7.2 (KCNQ2) channels, Kv7.2 + Kv7.3 channel, Kv7.2 channel, Inhibitor, M-current, Potassium Channel, PotassiumChannel, XE 991, XE 991 Dihydrochloride, XE 991 dihydrochloride, XE991, XE-991, XE991 Dihydrochloride, XE-991 Dihydrochloride
Field of Research
Pharmacology & Drug Discovery
Purity
98.68% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.11 mM) ; DMSO:12 mg/mL (26.7 mM)
Smiles
Cl.Cl.O=C1c2ccccc2C (Cc2ccncc2) (Cc2ccncc2) c2ccccc12
Molecular Formula
C26H22Cl2N2O
Molecular Weight
449.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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