MRT67307
MRT67307 is a potent kinase inhibitor targeting TBK1, IKKε, SIKs, and ULK1/2, thereby blocking autophagy. It modulates innate immune responses in macrophages by suppressing IRF3 phosphorylation and IFN-β while enhancing TLR-induced IL-10 and IL-1ra. This tool compound is widely used in autophagy and immunology research, applicable in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1190378-57-4
Product Name Alternative
IκB, IkB, IkB/IKK, IKK, IKKε, IKKε, MRT 67307, MRT67307, MRT-67307, MRT67307 HCl, Autophagy, ULK2, ULK1, ULK, transduction, signal, TBK1, TBK-1
Field of Research
Cell Biology, Signal Transduction
Purity
99.25% (May vary between batches)
Solubility
Ethanol:83 mg/mL (178.65 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM) ; DMSO:120 mg/mL (258.29 mM)
Smiles
O=C (NCCCNc1nc (Nc2cccc (CN3CCOCC3) c2) ncc1C1CC1) C1CCC1
Molecular Formula
C26H36N6O2
Molecular Weight
464.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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