Centrinone
Centrinone (LCR-263) is a potent and reversible small-molecule inhibitor of PLK4 with a Ki of 0.16 nM. It is widely used in biochemical and cellular studies to investigate centriole duplication and has been applied in both in vitro assays and in vivo models to explore its effects on cell cycle progression and genome stability.
Product Specifications
CAS Number
1798871-30-3
Product Name Alternative
Polo-like Kinase (PLK), PLK, PLK4 G95L, PLK4, Centrinone, Aurora Kinase, AuroraKinase, Aurora B, Aurora A, inhibit, LCR263, LCR-263, LCR 263, Inhibitor
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
98.58% (May vary between batches)
Solubility
DMSO:31 mg/mL (48.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.89 mM)
Smiles
COc1c (Nc2cc (C) [nH]n2) nc (Sc2ccc (cc2F) S (=O) (=O) Cc2cccc (c2F) [N+] ([O-]) =O) nc1N1CCOCC1
Molecular Formula
C26H25F2N7O6S2
Molecular Weight
633.65
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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