NVP-2
NVP-2 is a potent and selective ATP-competitive inhibitor of CDK9, inducing apoptosis with an IC50 of 0.514 nM. It also inhibits CDK1, CDK2, and CDK16 at micromolar concentrations. This probe is widely used in vitro to study transcription, cell cycle, and apoptosis mechanisms in cancer research.
Product Specifications
CAS Number
1263373-43-8
Product Name Alternative
CDK9, CDK, Cyclin dependent kinase, CRBN, Apoptosis, NVP 2, NVP2, NVP-2, Inhibitor, inhibit, Leukemia
Field of Research
Cell Biology
Purity
99.13% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.8 mM) ; DMSO:100 mg/mL (194.91 mM)
Smiles
COC[C@@H] (C) N[C@H]1CC[C@@H] (CC1) Nc1cc (c (Cl) cn1) -c1cccc (NCC2 (CCOCC2) C#N) n1
Molecular Formula
C27H37ClN6O2
Molecular Weight
513.07
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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